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Petersén Å and Weydt P. Handbook of Clinical Neurology 15: 179-189 (2019) Abstract Huntington disease (HD) is a hereditary neurodegenerative disorder caused by an expanded cytosine-adenine-guanine triplet repeat in the huntingtin gene. The current diagnosis is based on the presence of typical motor signs in combination with a positive gene test. The motor onset of the disease is usually between 30

https://www.huntington-research.lu.se/psychopharmacology-huntington-disease - 2025-11-07

Niemelä V, Petersén Å, Loutfi G, Svenningsson P and Paucar M. Läkartidningen. 2020;117:FU7H Abstract Huntington's disease is an autosomal dominant neurodegenerative disease that leads to premature death. The disease is caused by a pathological CAG triplet expansion in the huntingtin gene. The disease is most common in Western populations, with onset in middle age and causing progressive motor, cog

https://www.huntington-research.lu.se/recent-advances-huntingtons-disease - 2025-11-07

Rochel B, Domínguez D J F, Stout J, Gabery S, Churchyard A, Chua P, Egan G, Petersén A, Georgiou-Karistianis N and Poudel G R.Journal of the Neurological Sciences 364: 148-153 (2016)AbstractSubjective reports of sleep disturbance are a common feature of Huntington's disease (HD); however, there is limited research investigating the relationship between sleep with changes in brain and behaviour. Th

https://www.huntington-research.lu.se/subjective-sleep-problems-huntingtons-disease-pilot-investigation-relationship-brain-structure - 2025-11-07

Sanaz Gabery, Casper G. Salinas, Sarah J. Paulsen, Jonas Ahnfelt-Rønne, Tomas Alanentalo, Arian F. Baquero, Stephen T. Buckley, Erzsébet Farkas, Csaba Fekete, Klaus S. Frederiksen, Hans Christian C. Helms, Jacob F. Jeppesen, Linu M. John, Charles Pyke, Jane Nøhr, Tess T. Lu, Joseph Polex-Wolf, Vincent Prevot, Kirsten Raun, Lotte Simonsen, Gao Sun, Anett Szilvásy-Szabó, Hanni Willenbrock, Anna Sech

https://www.huntington-research.lu.se/semaglutide-lowers-body-weight-rodents-distributed-neural-pathways - 2025-11-07

Every year in November, the Faculty of Medicine at Lund University, together with the health care organization Region Skåne and the Eric K. Fernström Foundation, organize the Research Day in Malmö and Lund. This is an opportunity for the public to listen to researches presenting topical research. Each year has its own theme and in 2019 mental illness was the topic for the event, with talks, discus

https://www.huntington-research.lu.se/research-day-2019 - 2025-11-07

2023Knut and Alice Wallenberg Foundation has in cooperation with Åsa Petersén produced a short film about Huntington's disease and Petersén's research on HD.Link to the movie "Huntington's disease - the hunt for treatment" on YouTube (opens in a new window)The European Huntington Disease Network (EHDN) elected Åsa Petersén member of the executive committee. The EHDN is a nonprofit research network

https://www.huntington-research.lu.se/highlights - 2025-11-07

Cheong RY, Tonetto S, von Hörsten S and Petersén Å. Psychoneuroendocrinology 119, 104773 (2020) Abstract Neuropsychiatric disturbances with altered social cognition, depression and anxiety are among the most debilitating early features in the fatal neurodegenerative disorder Huntington disease (HD) which is caused by an expanded CAG repeat in the huntingtin gene. The underlying neurobiological mec

https://www.huntington-research.lu.se/imbalance-oxytocin-vasopressin-system-contributes-neuropsychiatric-phenotype-bachd-mouse-model - 2025-11-07

Follin C1, Gabery S2, Petersén Å2, Sundgren PC3, Björkman-Burtcher I3,4, Lätt J3, Mannfolk P3 and Erfurth EM1.1Department of Endocrinology, Skåne University hospital and IKVL, Lund University, Lund, Sweden.2Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.3Department of Diagnostic Radiology, Skåne University Hospital and IKVL/Lun

https://www.huntington-research.lu.se/associations-between-metabolic-risk-factors-and-hypothalamic-volume-childhood-leukemia-survivors - 2025-11-07

Fjalldal S, Rylander L, van Westen D, Holmer H, Follin C, Gabery S, Petersen Å and Erfurth E M. Clinical Endocrinology (Oxf). 94(1): 48-57 (2021) Abstract Context: White matter lesions (WML) are caused by obstruction of small cerebral vessels associated with stroke risk. Craniopharyngioma (CP) patients suffer from increased cerebrovascular mortality. Objective: To investigate the effect of reduced

https://www.huntington-research.lu.se/brain-white-matter-lesions-are-associated-reduced-hypothalamic-volume-and-cranial-radiotherapy - 2025-11-07

In March 2024 Sofia Bergh, PhD student in TNU, gave two presentations on Huntington disease during the NMT Days. This is an annual event, arranged by the Faculty of Science, the Faculty of Medicine and the Faculty of Engineering at Lund University. A week of talks and demonstrations on a variety of topics show today’s research, and students in upper secondary school and their teachers are the audi

https://www.huntington-research.lu.se/talks-movies - 2025-11-07

Accessibility of huntington-research.lu.se This website is run by the research group Translational Neuroendocrinology. We want as many people as possible to be able to use this website, and this document describes how huntington-research.lu.se complies with the accessibility regulations, any known accessibility issues, and how you can report problems so that we can fix them. How accessible is hunt

https://www.huntington-research.lu.se/accessibility-statementold - 2025-11-07

Soylu-Kucharz R1, Adlesic N1, Baldo B1, Kirik D2 and Petersén Å1.1Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Sweden.2Brain Repair and Imaging in Neural Systems (B.R.A.I.N.S.) Unit, Department of Experimental Medical Sciences Lund University, Sweden.Sci Rep. Sep 30;5:14598 (2015)AbstractExpression of mutant huntingtin (htt) protein has

https://www.huntington-research.lu.se/hypothalamic-overexpression-mutant-huntingtin-causes-dysregulation-brown-adipose-tissue - 2025-11-07

Åsa Petersén - clinician scientist TDP-43 key role in the hypothalamus Link to New paper from TNU published! | Huntington Research - Translational Neuroendocrine Research Unit TNU research The Translational Neuroendocrine Research Unit (TNU) focuses on Huntington’s disease (HD) and the spectrum of amyotrophic lateral sclerosis (ALS) and the behavioural variant of frontal temporal dementia (bvFTD).

https://www.huntington-research.lu.se/landing-page - 2025-11-07

Wagner L1,2,3, Wolf R2, Zeitschel U4, Rossner S4, Petersén Å5, Leavitt BR6, Kästner F7, Rothermundt M7,8, Gärtner UT2, Gündel D9, Schlenzig D3, Frerker N10, Schade J10, Manhart S2, Rahfeld JU1,3, Demuth HU3 and von Hörsten S10.1Deutschsprachige Selbsthilfegruppe für Alkaptonurie (DSAKU) e.V., Stuttgart, Germany.2Probiodrug AG, Halle, Germany.3Fraunhofer-Institute for cell therapy and immunology, D

https://www.huntington-research.lu.se/proteolytic-degradation-neuropeptide-y-npy-head-toe-identification-novel-npy-cleaving-peptidases-and - 2025-11-07

Our team of highly skilled staff has long experience in translational research. Visit us Find your way to us in Lund. Åsa Petersén Group leader, Professor Email: Asa [dot] Petersen [at] med [dot] lu [dot] se Telephone: +46 46 222 16 86 Sanaz Gabery Guest researcher Email: Sanaz [dot] Rasoly_Gabery [at] med [dot] lu [dot] se Sofia Bergh PhD student Email: Sofia [dot] Bergh [at] med [dot] lu [dot] s

https://www.huntington-research.lu.se/team - 2025-11-07

Lilja Andersson P1, Petersén Å1, Graff C2 and Edberg A-K3.1Lund University, Sweden2Karolinska Institute, Sweden 3Kristianstad University, SwedenNursing Ethics. Apr 21 (2015)AbstractBackground: A predictive genetic test for Huntington’s disease can be used before any symptoms are apparent, but there is only sparse knowledge about the long-term consequences of a positive test result. Such knowledge

https://www.huntington-research.lu.se/ethical-aspects-predictive-test-huntingtons-disease-long-term-perspective - 2025-11-07

Gabery S, Halliday G, Kirik D, Englund E, Petersén Å.Neuropathol Appl Neurobiol. 41(6): 843-848 (2015)No abstract available.Full text article - on Wiley's website

https://www.huntington-research.lu.se/selective-loss-oxytocin-and-vasopressin-hypothalamus-early-huntington-disease-case-study - 2025-11-07

Gabery S1, Georgiou-Karistianis N2, Lundh SH1, Cheong RY1, Churchyard A3, Chua P4, Stout JC2, Egan GF5, Kirik D6 and Petersén Å1.1Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.2School of Psychological Sciences, Monash University, Clayton, Victoria, 3180, Australia.3School of Psychological Sciences, Monash University, Clayton,

https://www.huntington-research.lu.se/volumetric-analysis-hypothalamus-huntington-disease-using-3t-mri-image-hd-study - 2025-11-07

Breimer P, Petersén Å and Widner H. Lakartidningen. 2021;118:20126. (2021) Abstract Huntington disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. It is inherited in an autosomal dominant fashion with full penetrance. Around 15% of cases arise from spontaneous expansion of the CAG repeat. The clinical presentation includes involuntary m

https://www.huntington-research.lu.se/recurrent-psychotic-symtoms-over-several-years-were-caused-huntingtonsdisease - 2025-11-07

Wiesner D, Sinniger J, Henriques A, Dieterlé S, Müller H, Rasche V, Ferger B, Dirrig-Grosch S, Soylu-Kucharz R, Petersén A, Walther P, Linkus B, Kassubek J, Wong PC, Ludolph AC and Dupuis L.Human Molecular Genetics 24(8): 2228-2240 (2015)AbstractMutations in components of the molecular motor dynein/dynactin lead to neurodegenerative diseases of the motor system or atypical parkinsonism. These muta

https://www.huntington-research.lu.se/low-dietary-protein-content-alleviates-motor-symptoms-mice-mutant-dynactindynein-mediated - 2025-11-07